TY - JOUR ID - 73249 TI - Inhibitory Effects of Swietenia Mahagoni Seeds Extract on Α-Glucosidase and Α-amylase JO - International Journal of Engineering JA - IJE LA - en SN - 1025-2495 AU - Md Norodin, N. S. AU - Md Salleh, L. AU - Yusof, N AU - Mustapha, N. M AU - Kamarulzaman, F AU - Mohamed Zahari, M. A AU - Bakeri, N. A AD - Center of Lipids Engineering and Applied Research (CLEAR), Ibnu Sina Institute Scientific & Industrial Research (Ibnu Sina ISIR), Universiti Teknologi Malaysia, Johor, Malaysia AD - Center of Lipids Engineering and Applied Research (CLEAR), Ibnu Sina Institute Scientific & Industrial Research (Ibnu Sina ISIR), Universiti Teknologi Malaysia, Johor, Malaysia AD - Advanced Membrane Technology Research Centre (AMTEC), Universiti Teknologi Malaysia, Skudai, Johor, Malaysia AD - Natural Product Division, Forest Research Institute Malaysia (FRIM), Selangor Darul Ehsan, Malaysia Y1 - 2018 PY - 2018 VL - 31 IS - 8 SP - 1308 EP - 1317 KW - Swietenia mahagoni seed KW - α KW - glucosidase enzyme KW - amylase enzyme KW - Supercritical Carbon Dioxide (SC KW - CO2) extraction DO - N2 - This study analyzed the inhibition activity of Swietenia mahagoni seeds extract on α-glucosidase and α-amylase enzymes inhibition assays.  Swietenia mahagoni seeds were extracted by using Supercritical Carbon Dioxide (SC-CO2) extraction at pressures of 20- 30 MPa and temperatures of 40- 60°C.  The oil yields obtained were analyzed with α- glucosidase and α- amylase enzymes inhibition assays.  All data obtained were expressed as mean ± standard deviation for triplicate experiments.  One way analysis was used for statistical significance by using Statistica software version 7.0 (StartSoft, EUA) and IC50 (extract concentration causing 50% enzyme inhibitory) was determined by using GraphPad Prism 6.0 software.  Swietenia mahagoni seeds extract have a strong inhibition of α-glucosidase enzyme activity (98.4% ± 0.2) but a moderate inhibition of α- amylase enzyme activity (34.9% ± 1.2). These findings implied that Swietenia mahagoni seeds extract could be an effective natural antidiabetic agent. UR - https://www.ije.ir/article_73249.html L1 - https://www.ije.ir/article_73249_5b75c9ebc188c87fa8900513ae08929b.pdf ER -