Inhibitory Effects of Swietenia Mahagoni Seeds Extract on Α-Glucosidase and Α-amylase


1 Center of Lipids Engineering and Applied Research (CLEAR), Ibnu Sina Institute Scientific & Industrial Research (Ibnu Sina ISIR), Universiti Teknologi Malaysia, Johor, Malaysia

2 Department of Bioprocess and Polymer Engineering, School of Chemical and Energy Engineering, University Teknologi Malaysia, Johor, Malaysia

3 Advanced Membrane Technology Research Centre (AMTEC), Universiti Teknologi Malaysia, Skudai, Johor, Malaysia

4 Natural Product Division, Forest Research Institute Malaysia (FRIM), Selangor Darul Ehsan, Malaysia


This study analyzed the inhibition activity of Swietenia mahagoni seeds extract on α-glucosidase and α-amylase enzymes inhibition assays.  Swietenia mahagoni seeds were extracted by using Supercritical Carbon Dioxide (SC-CO2) extraction at pressures of 20- 30 MPa and temperatures of 40- 60°C.  The oil yields obtained were analyzed with α- glucosidase and α- amylase enzymes inhibition assays.  All data obtained were expressed as mean ± standard deviation for triplicate experiments.  One way analysis was used for statistical significance by using Statistica software version 7.0 (StartSoft, EUA) and IC50 (extract concentration causing 50% enzyme inhibitory) was determined by using GraphPad Prism 6.0 software.  Swietenia mahagoni seeds extract have a strong inhibition of α-glucosidase enzyme activity (98.4% ± 0.2) but a moderate inhibition of α- amylase enzyme activity (34.9% ± 1.2). These findings implied that Swietenia mahagoni seeds extract could be an effective natural antidiabetic agent.


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